The University of Southampton
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mdp@ecs.soton.ac.uk

Dr Maurits de Planque

Academic Staff

As Associate Professor at the Life Sciences Interface of ECS my main research interests are nano/microtechnology aspects of bioengineering, including chemical oscillators, microfluidic cell arrays, semiconductor biosensors and ion channel nanopores. Before I came to Southampton I worked as a postdoctoral fellow in Melbourne and in Oxford, after obtaining an integrated masters in (bio)chemistry and a PhD in biophysics in Utrecht. I collaborate with a wide range of scientists and engineers, from molecular biologists to clean room experts. I host engineers who are interested in biomedical applications of fabrication methodology as well as bioscientists who are keen to gain experience with biodevices at the micro-nanoscale. Please have a look at the 'Research' tab for a selection of current projects and a description of the facilities that I use for my work. My publications in scientific journals (excluding conference proceedings etc) can be found at Google Scholar, with a full list under the 'Publications' tab. In terms of education, I deliver taught modules on fabrication and on biosensing and supervise bioengineering projects for undergraduate and MSc students. I am also Director of MSc Programmes and sit on the University's Academic Quality and Standards Committee (AQSC).

Research

Research interests

I work at the interface between the material sciences and the life sciences, a rapidly growing research area that includes bioengineering and bionanotechnology. My main interest is the interaction between nano/microfabricated materials and biomolecules, specifically in the context of cell membranes and their molecular components.

My present projects include microfabrication approaches for single-molecule and single-cell biomedical studies such as ion channel drug screening and nanoparticle drug delivery, nanopore resistive pulse sensors and nanoscale field effector transistors for biomarker detection, as well as self-assembled biochemical networks. Please see the links below for more detail on current research. All this work -which is suitable for engineers and bioscientists alike- is performed in close collaboration with electronic engineers in ECS and with scientists in Biological Sciences, Chemistry and Medicine departments.

I manage a range of instruments, including a confocal fluorescence microscope, an environmental scanning electron microscope, a nanoparticle zetasizer and an electrophysiology setup. I have access to all the facilities of the Southampton Nanofabrication Centre and am also involved with the Institute for Life Sciences. Most of my people work in the Hybrid Biodevices laboratories (web site under construction) located in the new Life Sciences building, and in the rapid prototyping clean room and measurement labs, located in the main Electronics complex.

Current PhD students

Mr Antonio De Grazia - Microfluidic characterization of stem cell heterogeneity

Mr Josip Ivica - Nanopore resistive pulse sensing

Mr Kai Ming Chang - Compartmentalized chemical oscillators

Past PhD students

Mr Hang Lu - ProteoGUV platforms

Dr Hend Alkhammash - Microfluidic white blood cell arrays

Dr Prameen Kalikavunkal - Microvolume dialysis for blood desalting

Dr Sumit Kalsi - 3D lithography of shaped lipid bilayer apertures

Dr Mark Friddin - Protein expression in microsystems

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Projects

Publications

de Planque, M.R.R., Raussens, V., Antoranz Contera, S., Rijkers, D.T.S., Liskamp, R.M.J., Ruysschaert, J-M., Ryan, J.F., Separovic, F. and Watts, A. (2007) Beta-sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes. Journal of Molecular Biology, 368, (4), 982-997. (doi:10.1016/j.jmb.2007.02.063).

Ramanujan, C.S., Sumitomo, K., de Planque, M.R.R., Hibino, H., Torimitsu, K. and Ryan, J.F. (2007) Self-assembly of vesicle nanoarrays on Si: a potential new route to high-density functional protein arrays. Applied Physics Letters, 90, (3), 033901-033903. (doi:10.1063/1.2431774).

Lemaître, V., de Planque, M.R.R., Howes, A.P., Smith, M.E., Dupree, R. and Watts, A. (2004) Solid-State 17O NMR as a Probe for Structural Studies of Proteins in Biomembranes. Journal of the American Chemical Society, 126, (47), 15320-15321. (doi:10.1021/ja0473283).

de Planque, M.R.R., Goormaghtigh, E., Greathouse, D.V., Koeppe II, R.E., Kruijtzer, J.A.W., Liskamp, R.M.J., de Kruijff, B. and Killian, J.A. (2001) Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: Effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40, (16), 5000-5010. (doi:10.1021/bi000804r).

Marius, Phedra, de Planque, Maurits R.R. and Williamson, Philip T.F. (2011) Probing the interaction of lipids with the non-annular binding sites of the potassium channel KcsA by magic-angle spinning NMR. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818, (1), 90-96. (doi:10.1016/j.bbamem.2011.09.017). (PMID:21963409).

Toledo, N C, de Planque, M R R, Antoranz Contera, S, Grobert, N and Ryan, J F (2007) Lipid-modulated assembly of magnetized iron-filled carbon nanotubes in millimeter-scale structures. Japanese Journal of Applied Physics, 46, (4B), 2799-2805.

Ambroggio, EE, Villarreal, MA, Montich, GG, Rijkers, DTS, de Planque, MRR, Separovic, F and Fidelio, GD (2006) Interfacial properties of the M1 segment of the nicotinic acetylcholine recepter. Biophysical Chemistry, 121, (3), 171-176.

Antoranz Contera, S, Lemaître, V, de Planque, M R R, Watts, A and Ryan, J F (2005) Unfolding and Extraction of a Transmembrane Alpha-Helical Peptide: Dynamic Force Spectroscopy and Molecular Dynamics Simulations. Biophysical Journal, 89, (5), 3129-3140.

de Planque, M R R, Rijkers, D T S, Fletcher, J I, Liskamp, R M J and Separovic, F (2004) The alphaM1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrance environment. Biochimica et Biophysica Acta, 1665, (1-2), 40-47.

de Planque, M R R, Rijkers, D T S, Liskamp, R M J and Separovic, F (2004) The alphaM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry, 42, (2), 148-154.

de Planque, M R R, Bonev, B B, Demmers, J A A, Greathouse, D V, Koeppe II, R E, Separovic, F, Watts, A and Killian, J A (2003) Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions. Biochemistry, 42, (18), 5341-5348.

Marcotte, I, Wegener, K L, Lam, Y H, Chia, B C S, de Planque, M R R, Bowie, J H, Auger, M and Separovic, F (2003) Interaction of antimicrobial peptides from Australian amphibians with lipid membranes. Chemistry and Physics of Lipids, 122, (1-2), 107-120.

Ali, M, de Planque, M R R, Huynh, N T, Manolios, N and Separovic, F (2002) Biophysical studies of a transmembrane peptide derived from the T cell antigen receptor. International Journal of Peptide Research and Therapeutics, 8, (3-5), 227-233.

de Planque, M R R, Boots, J W P, Rijkers, D T S, Liskamp, R M J, Greathouse, D V and Killian, J A (2002) The Effects of Hydrophobic Mismatch between Phosphatidylcholine Bilayers and Transmembrane Alpha-Helical Peptides Depend on the Nature of Interfacially Exposed Aromatic and Charged Residues. Biochemistry, 41, (26), 8396-8404.

de Planque, M R R, Kruijtzer, J A W, Liskamp, R M J, Marsh, D, Greathouse, D V, Koeppe II, R E, de Kruijff, B and Killian, J A (1999) Different Membrane Anchoring Positions of Tryptophan and Lysine in Synthetic Transmembrane Alpha-Helical Peptides. Journal of Biological Chemistry, 274, (30), 20839-20846.

de Planque, M R R, Greathouse, D V, Koeppe II, R E, Schäfer, H, Marsh, D and Killian, J A (1998) Influence of Lipid/Peptide Hydrophobic Mismatch on the Thickness of Diacylphosphatidylcholine Bilayers. A 2H NMR and ESR Study Using Designed Transmembrane Alpha-Helical Peptides and Gramicidin A. Biochemistry, 37, (26), 9333-9345.

Killian, J A, Salemink, I, de Planque, M R R, Lindblom, G, Koeppe II, R E and Greathouse, D V (1996) Induction of Nonbilayer Structures in Diacylphosphatidylcholine Model Membranes by Transmembrane Alpha-Helical Peptides: Importance of Hydrophobic Mismatch and Proposed Role of Tryptophans. Biochemistry, 35, (3), 1037-1045.

de Planque, M R R and Killian, J A (2003) Protein-lipid interactions studied with designed transmembrane peptides: role of hydrophobic matching and interfacial anchoring (Review). Molecular Membrane Biology, 20, 271-284.

Killian, J A, de Planque, M R R, van der Wel, P C A, Salemink, I, de Kruijff, B, Greathouse, D V and Koeppe II, R E (1998) Modulation of membrane structure and function by hydrophobic mismatch between proteins and lipids. Pure and Applied Chemistry, 70, (1), 75-82.

Burch, Hilary J., Antoranz Contera, Sonia, de Planque, Maurits R.R., Grobert, Nicole and Ryan, John F. (2008) Doping of carbon nanotubes with nitrogen improves protein coverage whilst retaining correct conformation. Nanotechnology, 19, (38), 384001. (doi:10.1088/0957-4484/19/38/384001).

Sun, Kai, Hakim, M.M.A., Kong, J., de Planque, M.R.R., Morgan, H., Roach, P.L., Davies, D.E., Howarth, P. and Ashburn, P. (2010) Low cost nanowire biosensor fabrication using thin film amorphous silicon crystallisation technologies. At IDRN, Leceister, UK, 14 May 2010.

Aghdaei, Sara, Heslington, Thomas, Rogers, Nik, Morgan, Hywel and de Planque, Maurits R.R. (2010) Assessment of nanoparticle cytotoxicity with on-chip suspended bilayers. In, Proceedings of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The , Netherlands, 03 - 07 Oct 2010. , 298-300.

Sun, K., Hakim, M.M.A., Kong, J., de Planque, M.R.R., Morgan, H., Roach, P.L., Davies, D.E., Howarth, P. and Ashburn, P. (2010) Polycrystalline silicon nanowires patterned by top-down lithography for biosensor applications. Micro and Nano Engineering, Genoa, Italy, 19 - 22 Sep 2010.

Sun, K., Hakim, M.M.A., Lombardini, M., Davies, D.E., Roach, P.L., de Planque, M.R.R., Ashburn, P. and Morgan, H. (2010) Sensors for chemical detection based on top-down fabricated polycrystalline silicon nanowires. At NanoBioTech 2010, Montreux, Switzerland, 15 - 17 Nov 2010.

Szymanski, Jan, Gorecka, Joanna Natalia, Igarashi, Yasuhiro, Gizynski, Konrad, Gorecki, Jerzy, Zauner, Klaus-Peter and de Planque, Maurits R.R. (2011) Droplets with information processing ability. International Journal of Unconventional Computing , 7, (3), 185-200.

Morgan, Hywel and de Planque, Maurits R.R. (2010) Suspended lipid bilayers in microfluidic platforms. At NanoBioTech 2010, Montreux, Switzerland, 15 - 17 Nov 2010.

Aghdaei, Sara, Morgan, Hywel and de Planque, Maurits R.R. (2010) Silica nanoparticles permeabilize lipid bilayers. At 54th Annual Meeting of the Biophysical Society, San Francisco, USA, 20 - 24 Feb 2010. Biophysical Journal, 98 (3), 401a-402a.

de Planque, Maurits R.R., Aghdaei, Sara, Roose, Tiina and Morgan, Hywel (2011) Electrophysiological characterization of membrane disruption by nanoparticles. ACS Nano, 5, (5), 3599-3606. (doi:10.1021/nn103320j).

King, P.H., Corsi, J.C., Morgan, H., de Planque, M.R.R. and Zauner, K.P. (2011) Towards on-chip on-demand microfluidic production and manipulation of droplets for chemical computing. At BioChemIT - 1st COBRA Workshop on Biological and Chemical Information Technologies, Paris, France, 08 Aug 2011.

Corsi, J.C., King, P.H., Morgan, H., de Planque, M.R.R. and Zauner, K.P. (2011) Belousov-Zhabotinsky oscillations inside lipid-enclosed droplets. At BioChemIT - 1st COBRA Workshop on Biological and Chemical Information Technologies, Paris, France, 08 Aug 2011.

de Planque, M.R.R. (2011) Effect of nanoparticle attachment on cell membrane integrity. In, Topics in Particle and Dispersion Science. , TPDSci Inc.

King, Philip H., Corsi, Josephine C., Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2011) Microlitre droplet-in-oil arrays via rapid direct manufacture. At NanoBioTech 2011, Montreux, Switzerland, 14 - 16 Nov 2011.

Lombardini, Marta, Al Hakim, Mohammad, Sun, Kai, Broder, Graham, Giustiniano, Francesco, de Planque, Maurits R.R., Roach, Peter, Davies, D.E., Howarth, P.H., Morgan, Hywel and Ashburn, Peter (2011) Inflammatory biomarker sensing using rectangular polycrystalline silicon nanowires made by dry etching. In, Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, USA, 02 - 06 Oct 2011. , 1086-1088.

King, Philip, Corsi, Josephine C., Pan, Ben-Hong, Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2012) Towards molecular computing: co-development of microfluidic devices and chemical reaction media. Biosystems, 109, (1), 18-23. (doi:10.1016/j.biosystems.2012.01.003).

Al Hakim, Mohammad M., Lombardini, Marta, Sun, Kai, Giustiniano, Francesco, Roach, Peter L., Davies, Donna E., Howarth, Peter H., de Planque, Maurits R.R., Morgan, Hywel and Ashburn, Peter (2012) Thin film polycrystalline silicon nanowire biosensors. Nano Letters, 12, (4), 1868-1872. (doi:10.1021/nl2042276). (PMID:22432636).

Alkhammash, H.I., Li, N., Yang, S. and de Planque, M.R.R (2012) Silica nanosphere-induced membrane damage is modulated by nanoparticle diameter, surface chemistry and biocoating. At Colloids and Nanomedicine 2012, Amsterdam, The Netherlands, 15 - 17 Jul 2012.

Mohamed Sultan, Suhana, Sun, Kai, de Planque, Maurits R.R., Ashburn, Peter and Chong, Harold M H (2012) Top-down fabricated ZnO nanowire transistors for application in biosensors. 42nd European Solid State Device Research Conference, Bordeaux, France, 17 - 21 Sept 2012.

Abraham, Chinnu M., King, Philip H., Zauner, Klaus-Peter and de Planque, Maurits R.R. (2012) Selective propagation of Belousov-Zhabotinsky waves in milliscale channels. In, BioChemIT: 2nd COBRA Workshop on Biological and Chemical Information Technologies, Orléans, France, 03 - 07 Sep 2012.

Jones, Gareth, King, Philip H., Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2012) Autonomous droplets: from neurons to muscles. In, BioChemIT: 2nd COBRA Workshop on Biological and Chemical Information Technologies, Orléans, France, 03 - 07 Sep 2012.

Nagulapalli, Malini, Parigi, Giacomo, Yuan, Jing, Gsponer, Joerg, Deraos, George, Bamm, Vladimir V., Harauz, George, Matsoukas, John, de Planque, Maurits R.R., Gerothanassis, Ioannis P., Babu, M. Madan and Tzakos, Andreas G. (2012) Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex. Structure, 20, (3), 522-533. (doi:10.1016/j.str.2012.01.021). (PMID:22405011).

Powl, A.M., de Planque, M.R.R., Morgan, H. and Wallace, B.A. (2010) The NaChBac pore: creation and characterisation of a KcsA-like sodium channel. Biophysical Journal, 98, (3), supplement S1, p.7a. (doi:10.1016/j.bpj.2009.12.043).

de Planque, M.R.R., Toledo, N.C., Contera, S.A. and Ryan, J.F. (2007) Lipid bilayer functionalization of multiwalled carbon nanotubes. In, 51st Annual Meeting of the Biophysical Society, Baltimore, US, 03 - 07 Mar 2007. 1pp, 552a-552a.

de Planque, M.R.R., Contera, S.A., Raussens, V., Rijkers, D.T.S., Ryan, J.F., Separovic, F. and Watts, A. (2006) Beta-sheet structured oligomers of Alzheimer's beta-amyloid peptide perturb phosphatidylcholine model membranes. FEBS Journal, 273, supplement S1, 240-240. (doi:10.1111/j.1742-4658.2006.05277.x).

de Planque, M.R.R., Contera, S.A., Mendes, G.P., Rijkers, D.T.S., Ryan, J.F. and Watts, A. (2005) Characterization of beta-amyloid(1-40) incorporated in model membranes: peptide conformation, acyl chain order, vesicle morphology, supported bilayer topography, and channel activity. FEBS Journal, 272, supplement S1, 235-236. (doi:10.1111/j.1742-4658.2005.4739_5.x).

Mendes, G.P., de Planque, M.R.R., Grage, S.L., Berry, R. and Watts, A. (2005) Incorporation of the mechanosensitive channel (MscL) and the amyloid Abeta[1-40] peptide by vesicle fusion into planar lipid bilayers. FEBS Journal, 272, supplement S1, 342-342. (doi:10.1111/j.1742-4658.2005.4739_8.x).

Friddin, Mark S., Smithers, Natalie P., Lee, Anthony G., Morgan, Hywel and de Planque, Maurits R.R. (2012) Cell-free expression and electrophysiological measurements of the KcsA channel with interdroplet bilayers. At NanoBioTech 2012, Montreux, CH, 12 - 14 Nov 2012.

Friddin, Mark S., Morgan, Hywel and de Planque, Maurits R.R. (2013) Cell-free protein expression systems in microdroplets: stabilization of interdroplet bilayers. Biomicrofluidics, 7, (1), 014108. (doi:10.1063/1.4791651).

Kalsi, Sumit, Morgan, Hywel and de Planque, Maurits R.R. (2013) Suspended bilayers in shaped apertures enable 24-hour ion channel recordings. At 57th Annual Meeting of the Biophysical Society, Philadelphia, US, 02 - 06 Feb 2013.

Alkhammash, Hend I., Li, Nan, Yang, Shuangfan and de Planque, Maurits R.R. (2013) Membrane disruption by silica nanospheres is modulated by surface chemistry and biocoating. At 57th Annual Meeting of the Biophysical Society, Philadelphia, US, 02 - 06 Feb 2013.

King, Philip H., Abraham, Chinnu H., Zauner, Klaus-Peter and de Planque, Maurits R.R. (2015) Excitability modulation of oscillating media in 3D-printed structures. Artificial Life, 21, (2), 225-233. (doi:10.1162/ARTL_a_00158). (PMID:25622017).

Friddin, Mark S., Smithers, Natalie P., Lee, Anthony G., Morgan, Hywel and de Planque, Maurits R.R. (2013) Electrophysiology of a cell-free expressed potassium channel in microdroplets without protein purification. At Advances in Microfluidics and Nanofluidics (AMN2013), Notre Dame, Indiana, US, 24 - 26 May 2013.

King, Philip H., Jones, Gareth, Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2013) Belousov-Zhabotinsky droplet mixing on-chip for chemical computing applications. At 3rd COBRA Workshop on Biological and Chemical IT, Milan, Italy, 05 Jul 2013.

Kiang, Kian Shen, Kalsi, Sumit, Ritter, Daniel, Unal, Nezih, Morgan, Hywel, Anteney, Iain, Chong, Harold M. H. and de Planque, Maurits R.R. (2013) Fabrication of tapered edgewall apertures using grayscale lithography. At 39th International Conference on Micro and Nano Engineering, London, GB, 16 - 19 Sep 2013.

Saha, Shimul Chandra, Thei, Federico, de Planque, Maurits R.R. and Morgan, Hywel (2013) Scaleable BLM arrays for parallel ion channel recording. At 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Freiburg, Germany, 27 - 31 Oct 2013.

Friddin, Mark S., Smithers, Natalie P., Lee, Anthony G., Morgan, Hywel and de Planque, Maurits R.R. (2013) Ion channel characterization with microdroplets of protein expression mixtures. At 7th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2013), Phuket, TH, 10 - 13 Nov 2013.

Kalikavunkal, Prameen C. and de Planque, Maurits R.R. (2013) Cross-flow dialysis for microvolume desalting. At NanoBioTech 2013, Montreux, Switzerland, 18 - 20 Nov 2013.

Beaugrand, Maïwenn, Kalsi, Sumit, Gravel, Andrée E., Johnson, Christopher D., Wright, J. Neville, Young, Jason C., de Planque, Maurits R.R., Marcotte, Isabelle and Williamson, Philip T.F. (2014) Expression and purification of a functional hERG pore domain for biophysical and electrophysiological studies. At 58th Annual Meeting of the Biophysical Society, San Francisco, US, 15 - 19 Feb 2014.

King, Philip H., Jones, Gareth, Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2014) Interdroplet bilayer arrays in millifluidic droplet traps from 3D-printed moulds. Lab on a Chip, 14, 722-729. (doi:10.1039/C3LC51072G).

Friddin, Mark S., Smithers, Natalie P., Beaugrand, Maïwenn, Marcotte, Isabelle, Williamson, Philip T.F., Morgan, Hywel and de Planque, Maurits R.R. (2013) Single-channel electrophysiology of cell-free expressed ion channels by direct incorporation in lipid bilayers. Analyst, 138, (24), 7294-7298. (doi:10.1039/C3AN01540H).

Kalsi, Sumit, Powl, Andrew M., Wallace, B.A., Morgan, Hywel and de Planque, Maurits R.R. (2014) Shaped apertures in photoresist films enhance the lifetime and mechanical stability of suspended lipid bilayers. Biophysical Journal, 106, (8), 1650-1659. (doi:10.1016/j.bpj.2014.02.033).

Crescentini, Marco, Thei, Federico, Bennati, Marco, Saha, Shimul C., de Planque, Maurits R.R., Morgan, Hywel and Tartagni, Marco (2014) A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation. IEEE Transactions on Biomedical Circuits and Systems, 9, 334-344. (doi:10.1109/TBCAS.2014.2346402). (PMID:25252284).

Saha, Shimul C., Thei, Federico, de Planque, Maurits R.R. and Morgan, Hywel (2014) Scaleable micro-cavity bilayer lipid membrane array for parallel ion channel recording. Sensors and Actuators B: Chemical, 199, 76-82. (doi:10.1016/j.snb.2014.03.111).

Sun, Kai, Zeimpekis, Ioannis, Lombardini, Marta, Ditshego, N.M. Jack, Pearce, Stuart J., Kiang, Kian Shen, Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2014) Three mask polysilicon thin film transistor biosensor. IEEE Transactions on Electron Devices, 61, (6), 2170-2176. (doi:10.1109/TED.2014.231566).

Jones, Gareth, King, Philip H., Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2015) Autonomous droplet architectures. Artificial Life, 21, (2), 195-204. (doi:10.1162/ARTL_a_00156). (PMID:25622015).

Wang, Jiajun, de Planque, Maurits R.R., Kreir, Mohamed and Fertig, Niels (2014) Resistive pulse sensing with biological nanopores. At International Workshop on High-Throughput Bilayer Electrophysiology, Munich, Germany, 21 - 22 Jul 2014.

Kalikavunkal, Prameen C. and de Planque, Maurits R.R. (2014) Cross-flow dialysis for microvolume desalting. At RSC Analytical Research Forum 2014, London, GB, 07 Jul 2014.

Ditshego, N.M. Jack, Sun, Kai, Zeimpekis, Ioannis, de Planque, Maurits R.R., Ashburn, Peter and Chong, Harold M.H. (2014) Effects of surface passivation on top-down ZnO nanowire transistors. At Micro and Nano Engineering, Lausanne, CH, 22 - 26 Sep 2014.

Alkhammash, Hend I. and de Planque, Maurits R.R. (2014) Nanoparticle-cell interactions studied with microfluidic blood cell arrays. At CHAINS2014-Chemistry as Innovation Science, Eindhoven, NL, 17 - 18 Nov 2014.

Kalsi, Sumit, Saha, Shimul C., Kiang, Kian Shen, de Planque, Maurits R.R. and Morgan, Hywel (2014) Micro-cavity array with shaped apertures for optically and electrically accessible suspended BLMs. At NanoBioTech 2014, Montreux, CH, 17 - 19 Nov 2014.

Sun, Kai, Zeimpekis, Ioannis, Hu, Chunxiao, Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2014) Top-down polysilicon nanowires by ion beam etching for biosensing applications. At Micro and Nano Engineering, Lausanne, CH, 22 - 26 Sep 2014.

Zeimpekis, Ioannis, Sun, Kai, Hu, Chunxiao, Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2014) A differential measurement technique to eliminate parasitic resistance effects in ion sensitive sensors. At Micro and Nano Engineering, Lausanne, CH, 22 - 26 Sep 2014.

Saha, Shimul C., Powl, Andrew M., Wallace, B. A., de Planque, Maurits R.R. and Morgan, Hywel (2015) Screening ion-channel ligand interactions with passive pumping in a microfluidic bilayer lipid membrane (BLM) chip. Biomicrofluidics, 9, 014103. (doi:10.1063/1.4905313).

Alkhammash, Hend I., Li, Nan, Berthier, Rémy and de Planque, Maurits R.R. (2015) Native silica nanoparticles are powerful membrane disruptors. Physical Chemistry Chemical Physics, 17, 15547-15560. (doi:10.1039/C4CP05882H). (PMID:25623776).

Zeimpekis, Ioannis, Sun, Kai, Hu, Chunxiao, Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2015) Study of parasitic resistance effects in nanowire and nanoribbon biosensors. Nanoscale Research Letters, 10, 79. (doi:10.1186/s11671-015-0794-6).

Crescentini, Marco, Bennati, Marco, Saha, Shimul C., Ivica, Josip, de Planque, Maurits R.R., Morgan, Hywel and Tartagni, Marco (2016) A low-noise transimpedance amplifier for BLM-based ion channel recording. Sensors, 16, (5, 709), 1-20. (doi:10.3390/s16050709).

de Planque, Maurits R.R., Toledo, Nashville C., Antoranz Contera, S. and Ryan, John F. (2006) Membranes as self-assembling coating of solid state device components: integration of submicron electrical circuitry with biological systems. In, 2006 International Conference on Solid State Devices and Materials, Yokohama, JP, 12 - 15 Sep 2006. 2pp, 5683.

Saha, Shimul C., Henderson, Alexander J., Powl, Andrew M., Wallace, B.A., de Planque, Maurits R.R. and Morgan, Hywel (2015) Characterization of the prokaryotic sodium channel NavSp pore with a microfluidic bilayer platform. PLoS ONE, 10, (7), 1-9. (doi:10.1371/journal.pone.0131286). (PMID:26147601).

Zeimpekis, Ioannis, Sun, Kai, Hu, Chunxiao, Ditshego, Nonofo M.J., Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2016) Dataset for Dual-Gate Polysilicon Nanoribbon Biosensors Enable High Sensitivity Detection of Proteins. doi:10.5258/SOTON/379790 [dataset]

Sun, Kai, Zeimpekis, Ioannis, Hu, Chunxiao, Ditshego, Nonofo M.J., Thomas, Owain, Chong, Harold M.H., de Planque, Maurits R.R., Morgan, Hywel and Ashburn, Peter (2016) Dataset for Effect of Subthreshold Slope on the Sensitivity of Nanoribbon Sensors. doi:10.5258/SOTON/380117 [dataset]

Ditshego, Nonofo M.J., Sun, Kai, Zeimpekis, Ioannis, Ashburn, Peter, de Planque, Maurits R.R. and Chong, Harold M.H. (2015) ZnO nanowire-FET for charge-based sensing of protein. In, 2015 IEEE 15th International Conference on Nanotechnology (IEEE NANO 2015), Rome, IT, 27 - 30 Jul 2015. IEEE, 801-804. (doi:10.1109/NANO.2015.7388733).

Ghazali, N.A.B., Ebert, Martin, Ditshego, Nonofo M.J., de Planque, Maurits R.R. and Chong, Harold M.H. (2015) Top-down Fabrication Optimisation of ZnO Nanowire FETs By Sidewall Smoothing. At 41st Micro and Nano Engineering Conference, Den Haag, NL, 21 - 24 Sep 2015.

Georgiades, Eleni, de Planque, Maurits R.R., Smith, Peter J. and O'Kelly, Ita M. (2015) Identification of a novel two-pore domain potassium channel in mitochondria. At 6th World Congress on Targeting Mitochondria, Berlin, DE, 28 - 30 Oct 2015.

Kalikavunkal, Prameen C. and de Planque, Maurits R.R. (2015) Microvolume tuneable dialyser for mass spectrometry. At 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), Gyeongju, KR, 25 - 29 Oct 2015.

Sun, Kai, Zeimpekis, Ioannis, Ditshego, Nonofo M.J., Hu, Chunxiao, Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2015) Top-down zinc oxide nanowires by ion beam etching for biosensing applications. At 41st International Conference on Micro and Nano Engineering (MNE 2015), Den Haag, NL, 21 - 24 Sep 2015.

Sun, Kai, Zeimpekis, Ioannis, Hu, Chunxiao, Ditshego, N.M.J., de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2016) Dataset for Low-cost Top-down Zinc Oxide Nanowire Sensors through a Highly Transferable Ion Beam Etching for Healthcare Applications. doi:10.5258/SOTON/383154 [dataset]

Ivica, Josip, Williamson, Philip T.F. and de Planque, Maurits R.R. (2016) Optimization of parameters for nanopore resistive pulse sensing of microRNA. At 60th Annual Meeting of the Biophysical Society, Los Angeles, US, 27 Feb - 02 Mar 2016.

Alkhammash, Hend I. and de Planque, Maurits R.R. (2014) Microfluidic white blood cell arrays. At RSC Analytical Research Forum 2014, London, GB, 07 Jul 2014.

Sun, Kai, Zeimpekis, Ioannis, Hu, Chunxiao, Ditshego, N.M.J., Thomas, Owain, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2016) Low-cost top-down zinc oxide nanowire sensors through a highly transferable ion beam etching for healthcare applications. Microelectronic Engineering, 153, 96-100.

Zeimpekis, Ioannis, Sun, Kai, Hu, Chunxiao, Ditshego, Nonofo, Owain, Thomas, de Planque, Maurits R.R., Chong, Harold M.H., Morgan, Hywel and Ashburn, Peter (2016) Dual-gate polysilicon nanoribbon biosensors enable high sensitivity detection of proteins. Nanotechnology, 27, (16), 1-8. (doi:10.1088/0957-4484/27/16/165502).

Ditshego, N.M.J., Sun, K., Zeimpekis, I., Ashburn, P., de Planque, M.R.R. and Chong, H.M.H. (2015) Effects of surface passivation on top-down ZnO nanowire transistors. Microelectronic Engineering, 145, 91-95. (doi:10.1016/j.mee.2015.03.013).

Antoranz Contera, Sonia, Voïtchovsky, Kislon, Hamnett, Hilary, Ramanujan, Chandra S., Toledo, Nashville, Lemaître, Vincent, de Planque, Maurits R.R., Watts, Anthony, Sumitomo, Koji, Torimitsu, Keiichi and Ryan, J.F. (2005) Bionanotechnology with membrane proteins: mechanics and electronics. 2005 International Conference on Solid State Devices and Materials, Kobe, JP, 12 - 15 Sep 2005. , 450-451.

Burch, Hilary J., Antoranz Contera, Sonia, Toledo, Nashville, de Planque, Maurits R.R., Grobert, Nicole, Voïtchovsky, Kislon and Ryan, J.F. (2006) Biosensing with CNx multi-wall carbon nanotubes. In, 2006 International Conference on Solid State Devices and Materials, Yokohama, JP, 12 - 15 Sep 2006. , 788-789.

De Grazia, Antonio, Evans, Nicholas D. and de Planque, Maurits R.R. (2016) Microfluidic cell arrays for characterization of stem cell differentiation. At European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2016, Uppsala, SE, 28 Jun - 01 Jul 2016.

Morgan, Hywel, Crescentini, Marco, Bennati, Marco, Saha, Shimul, Ivica, Josip, De Planque, Maurits and Tartagni, Marco (2016) A low-noise transimpedance amplifier for BLM-Based ion channel recording. doi:10.5258/SOTON/394680 [dataset]

Sun, Kai, Zeimpekis, Ioannis, Hu, Chunxiao, Ditshego, Nonofo M.J., Thomas, Owain, Chong, Harold M.H., de Planque, Maurits R.R., Morgan, Hywel and Ashburn, Peter (2016) Effect of subthreshold slope on the sensitivity of nanoribbon sensors. Nanotechnology, 27, 1-9.

Ivica, Josip, Williamson, Philip T.F. and de Planque, Maurits R.R. (2016) Quantification of microRNA with alpha-hemolysin nanopores. At Membrane Pores: from Structure and Assembly to Medicine and Technology (The Royal Society), London, GB, 27 - 28 Jun 2016.

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