The University of Southampton

Submicron fabrication of biomolecular patterns using optical methods

Date:
2002-2008
Themes:
Medical Engineering, Nanoelectronics
Funding:
BBSRC

We have developed a new method for writing of biomolecular patterns on silicon in sub-micron scales using the interference of light. In the first instance DNA patterned surfaces were fabricated. Covalent attachment of DNA oligonucleotides accessible towards hybridisation with a complementary sequence was achieved with very high density (one oligonucleotide per 16 nm²). Further development of the surface attachment chemistry has provided DNA modified patterned substrates for hybridisation with long DNA fragments.

Primary investigator

Secondary investigators

  • Tom Brown, School of Chemistry
  • Human Genetics, School of Medicine

Associated research group

  • Optoelectronics Research Centre
Share this project FacebookGoogle+TwitterWeibo

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×