The University of Southampton

Parallel Electrophysiological Characterization of Sodium Channels

integrated platform
Date:
2010-2014
Themes:
Healthcare in ECS, Microfluidics and Lab-on-a-chip, Bionanotechnology and Biosensors
Funding:
EPSRC

This proposal aims to exploit a novel platform for parallel on-chip electrophysiology, developed at the University of Southampton, for the functional characterization of a family of voltage-gated sodium channels, including human/bacterial chimeras, for which the expression, purification and reconstitution into liposomes is being developed at Birkbeck College. Specifically, the project will use this high-throughput platform to identify novel ligands/drugs that modulate the conductance properties of the sodium channels.

Primary investigators

Secondary investigators

  • Mr Sumit Kalsi
  • Dr Shimul Saha
  • Mr Alex Henderson (Birkbeck)
  • Dr Andy Powl (Birkbeck)

Partners

  • Birkbeck College, London
  • University of Bologna

Associated research groups

  • Nano Research Group
  • Southampton Nanofabrication Centre
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