The University of Southampton

Daniel Spencer

Academic Staff

After completing a degree in electronic engineering and PhD at Southampton, I have been a lecturer in the Nano group of ECS since 2012.  My research interests are into microelectronic and lab-on-a-chip systems for medical and healthcare applications.  During my PhD I developed microelectronic devices for high speed characterisation of biological cells and I am collaborating with industry partners to incorporate the technology into commercial devices.  I have been exploring applying this technology to portable point of care diagnostic test devices and have demonstrated CD4 count for HIV/Aids monitoring and for the characterisation of tumour cells.  I am currently researching combining characterisation systems with sample pre-processing techniques for “sample-in, answer-out” diagnostic platforms.  I am module leader for the fourth year Bionanotechnology course and I lecture on the Lab-on-a-chip and Biosensors modules.  I also supervise bionanotechnology based Part III and MSc individual projects.



Research interests




MEng (Hons): Electronic Engineering

PhD: Electronics Engineering (Bioelectronics)


Professional activities

Conferences attended



Barat, David, Spencer, Daniel, Benazzi, Giuseppe, Mowlem, Matthew Charles and Morgan, Hywel (2012) Simultaneous high speed optical and impedance analysis of single particles with a microfluidic cytometer. Lab on a Chip, 12 (1), 118-126.

Hollis, Veronica S, Holloway, Judith A., Harris, Scott, Spencer, Daniel, van Berkel, Cees and Morgan, Hywel (2012) Comparison of venous and capillary differential leukocyte counts using a standard hematology analyzer and a novel microfluidic impedance cytometer. PLoS ONE, 7 (9), e43702. (PMID:23028467)

Spencer, Daniel and Morgan, Hywel (2011) Positional dependence of particles in microfludic impedance cytometry. Lab on a Chip, 11, 1234-1239.

Zmijan, Robert, Spencer, Daniel C., Mowlem, Matthew C. and Morgan, Hywel (2011) Differentiation of micro spheres by narrow angle scattered light detection on low cost PMMA micro flow cytometer chip. At 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences [error in script], [error in script], [error in script]. . 02 - 06 Oct 2013. pp. 1263-1265.

Spencer, Daniel (2013) Advanced microfluidic impedance cytometry for point of care analysis. University of Southampton, Physical Sciences and Engineering, Doctoral Thesis, 210pp.

Spencer, Daniel, Elliott, Gregor R. and Morgan, Hywel (2013) Simultaneous fluorescence and impedance micro cytometry. At The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013) [error in script], [error in script], [error in script]. . 27 - 31 Oct 2013.

Spencer, Daniel, Hollis, Veronica and Morgan, Hywel (2012) Identification of tumour cells using microfluidic impedance cytometry. At NanoBioTech- Montreux [error in script], [error in script], [error in script]. .

Spencer, Daniel and Morgan, Hywel (2012) Miniaturised point-of-care full blood count. At Bringing Diagnostic Prototypes to the Point-of-Care [error in script], [error in script], [error in script]. .

Spencer, Daniel, Elliott, Gregor and Morgan, Hywel (2014) A sheath-less combined optical and impedance micro-cytometer. Lab on a Chip, 14 (16), 3064-3073. (doi:10.1039/c4lc00224e).

Spencer, Daniel, Hollis, Veronica and Morgan, Hywel (2014) Microfluidic impedance cytometry of tumour cells in blood. Biomicrofluidics, 8 (6), 64124.

Spencer, Daniel and Morgan, Hywel (2014) Single cell microfluidic impedance spectroscopy. At Dielectrophoresis 2014 [error in script], [error in script], [error in script]. . 14 - 16 Jul 2014.

Morgan, Hywel and Spencer, Daniel (2015) CHAPTER 10. Microfluidic impedance cytometry for blood cell analysis. In, Microfluidics for Medical Applications. [error in script], [error in script], [error in script]. Royal Society of Chemistry, pp. 213-241. ,

Xavier, Miguel, Rosendahl, Philipp, Herbig, Maik, Kräter, Martin, Spencer, Daniel, Bornhäuser, Martin, Oreffo, Richard O.C., Morgan, Hywel, Guck, Jochen and Otto, Oliver (2016) Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry. Integrative Biology, 8, 616-623. (doi:10.1039/c5ib00304k). (PMID:26980074)

Spencer, Daniel and Morgan, Hywel (2016) Data for 'High accuracy particle analysis using sheathless microfluidic impedance cytometry'. University of Southampton [Dataset]

Spencer, Daniel, Caselli, Frederica, Bisenga, Paolo and Morgan, Hywel (2016) High accuracy particle analysis using sheathless microfluidic impedance cytometry. Lab on a Chip, 1-8. (doi:10.1039/C6LC00339G).

McGrath, J.S., Honrado, C., Spencer, D., Horton, B., Bridle, H.L. and Morgan, H. (2017) Analysis of parasitic protozoa at the single-cell level using microfluidic impedance cytometry. Scientific Reports. (In Press)

Honrado, Carlos, Manuel Fernandes, McGrath, John, Spencer, Daniel, Horton, Ben, Bridle, Helen and Morgan, Hywel (2017) Dataset for "Analysis of Parasitic Protozoa at the Single-cell Level using Microfluidic Impedance Cytometry" article. University of Southampton doi:10.5258/SOTON/D0047 [Dataset]

Xavier, Miguel, Oreffo, Richard, Spencer, Daniel, Morgan, Hywel and de Andrés, María C. (2017) Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow: consequences for microfluidic cell sorting. Journal of the Royal Society Interface, 14 (133). (doi:10.1098/rsif.2017.0233).

Pritchard, Laura K., Spencer, Daniel I.R., Royle, Louise, Vasiljevic, Snezana, Krumm, Stefanie A., Doores, Katie J. and Crispin, Matthew (2015) Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance. Journal of Virology, 89 (13), 6952-6959. (doi:10.1128/JVI.00230-15).


Telephone: +442380592940


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