The University of Southampton

Submicron fabrication of biomolecular patterns using optical methods

Medical Engineering, Nanoelectronics

We have developed a new method for writing of biomolecular patterns on silicon in sub-micron scales using the interference of light. In the first instance DNA patterned surfaces were fabricated. Covalent attachment of DNA oligonucleotides accessible towards hybridisation with a complementary sequence was achieved with very high density (one oligonucleotide per 16 nm²). Further development of the surface attachment chemistry has provided DNA modified patterned substrates for hybridisation with long DNA fragments.

Primary investigator

Secondary investigators

  • Tom Brown, School of Chemistry
  • Human Genetics, School of Medicine

Associated research group

  • Optoelectronics Research Centre
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