The University of Southampton

New microsystem for better drug-testing

Published: 
6 July 2011
Illustration

A University of Southampton nanoscientist is working on a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.

Dr Maurits de Planque of the Nano Research Group at ECS-Electronics and Computer Science will develop a new method to investigate the ion channels that underlie these serious disorders and that are used to test the effectiveness of new drugs.

"At the moment, commercial testing of new drugs is carried out using ion channels in living cell membranes. This is a slow and difficult process, not least because producing too many channels actually kills the cells," said Dr de Planque.

The researchers therefore plan to produce these ion channels without using cells, which is possible with so-called cell-free expression mixtures, and to insert the channels in a very stable artificial cell membrane which should enable faster, less expensive drug testing. "Researchers have experimented with cell-free mixtures before, but they found that this method was not economical due to the amount of expensive biochemicals required," said Dr de Planque. "Our proposal to develop a new platform, which uses a couple of microlitres instead of millilitres, will be a very cost-effective way of doing this, particularly when the produced channel is directly inserted in a membrane for drug testing."

Dr de Planque is conducting this research over a two-year period in collaboration with biological scientists at the University of Southampton. He is Principal Investigator for the project: Microsystems for Coupled Expression and Electrophysiology of Ion Channels, which has been awarded a grant of £125,000 from the Engineering and Physical Sciences Research Council (EPSRC).

__

For further information about this news story contact Joyce Lewis; tel.+44(0)23 8059 5453

Share this article FacebookGoogle+TwitterWeibo

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×