Title: Multi-pore Nanopore Resistive Pulse Sensing for Molecular Diagnostics with salt-gradient
Abstract: Resistive pulse sensing is the operating mechanism of classical Coulter counters, which relate the rate of microparticle translocation over a micropore to the particle concentration of a solution in contact with the pore. MicroRNA analytics with resistive pulse sensing is advantageous because as a single molecule technique it does not rely on amplification.In my work, an enhanced sensitivity of nanopore resistive pulse sensing of miRNA with bilayer embedded alpha-hemolysin is achieved with the introduce of multiple nano pores and steep salt concentration gradient.